Evidence for a human leucocyte antigen-DM-induced structural change in human leucocyte antigen-DOβ

Human Leucocyte Antigen Matching Strategy

The human leucocyte antigen (HLA) system.

Since the discovery of the HLA system, over 40 years ago, we now have an understanding of the role of HLA molecules in the adaptive immune response, as well as in the alloimmune response experienced when foreign HLA is introduced into an individual via transplant, transfusion or pregnancy. Retrospective studies in the 1970s and 1980s illustrated the importance of matching for HLA antigens in tr...

Human leucocyte antigen phenotypes and gold-induced remissions in patients with rheumatoid arthritis.

To assess possible associations between human leucocyte antigens (HLA) and the achievement of remission during gold treatment, HLA typing was performed in 67 rheumatoid arthritis (RA) patients with a gold-induced remission and in 25 control RA patients who discontinued gold therapy because of lack of efficacy. Both groups of RA patients showed a significantly higher frequency of DR4 antigen and...

Human leucocyte antigen matching and donor selection for sibling bone marrow transplantation in India

Fifty one patients undergoing treatment for various diseases and disorders (leukaemia of different type, thallasaemia and anaemia) at Kothari Medical Centre, Kolkata and awaiting bone-marrow transplant, and their siblings were studied for their Human Leucocytes Antigen (HLA) compatibility. Forty of these patients had siblings available as probable donors. In eleven cases, planned pregnancy and ...

Polymerase chain reaction based human leucocyte antigen genotyping for the investigation of suspected gastrointestinal biopsy contamination.

BACKGROUND Mislabelling or contamination of surgical specimens may lead to diagnostic inaccuracy, particularly within gastrointestinal pathology when multiple small mucosal biopsy specimens are commonly taken, and where a tiny fragment of foreign tissue may be indistinguishable from true biopsy material using histological assessment alone. AIMS To assess the utility of polymerase chain reacti...